Certain variants of Apolipoprotein E (ApoE) have been linked to specific health conditions: ApoE2 is associated with type III hyperlipoproteinemia, while ApoE4 is associated with cardiovascular disease and Alzheimer’s disease. The ViennaLab Apo E StripAssay^® easily discriminates between the E2, E3, and E4 variants of ApoE.

ApoE

• ApoE has key roles in the transport of cholesterol and other lipids within blood circulation and the central nervous system.
• ApoE is polymorphic exhibiting three different alleles, which differ by an alternating combination of two amino acids at position 112 and 158: E2 (C112_C158), E3 (C112_R158) and E4 (R112_R158).
• ApoE is an important predictor of the plasma lipid profile. On average, LDL-cholesterol concentrations are lower for ApoE2 carriers and higher for ApoE4 carriers compared to homozygous ApoE3 carriers.
• ApoE2 has been linked to an increased risk of cardiovascular disease, while ApoE4 is associated with a higher susceptibility to both Alzheimer's disease and coronary artery disease, according to various studies
• Identifying genetic variations in combination with timely life style adaptations may contribute to delay of disease onset.

pdf Productnote 01: CVD Marker