Characterize individual TPMT isoforms and avoid toxic effects of thiopurine treatment.

Thiopurine-based therapeutic drugs may accumulate to toxic levels in patients carrying genetic variants of the drug-metabolizing enzyme TPMT. The PGX-TPMT StripAssay® identifies the most frequent TPMT variants of therapeutic relevance.

 

PGX-TPMT

 

  • Thiopurines are widely used in the treatment of leukemias and autoimmune disorders, and as immunosuppressants after organ transplantation.
  • Thiopurine compounds are converted to therapeutically inactive metabolites by thiopurine S-methyltransferase (TPMT). Certain TPMT isoforms have substantially reduced activity leading to elevated thiopurine blood levels at standard dosage. Subsequent toxic myelosuppression may occur and may lead to life-threatening conditions.
  • Assessment of the patient’s TPMT isoform is a prerequisite for avoiding toxic effects of thiopurine treatment.

 

ProductREFUnit SizeIFUBrochure
PGX-TPMT StripAssay®4-74020 tests

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