Genetically determined enzyme and transporter deficiencies may cause hereditary intolerance to common dietary sugars. ViennaLab assays identify the most frequent genetic variations responsible for sugar intolerance.

Sugar Intolerance

• Lactose intolerance is a frequent autosomal recessive condition causing diarrhea, nausea and flatulence. The disease is strongly associated with genetic variants regulating the expression of the lactase (LCT) gene.
• Hereditary fructose intolerance is an autosomal recessive disorder caused by variants of the aldolase B (ALDOB) gene. Affected subjects suffer from abdominal pain, vomiting, hypoglycemia, and unless fructose-containing food is strictly avoided may even die from organ damage.
• ViennaLab assays are available for the detection of two LCT and four ALDOB genetic variants.

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Citations:

1. Németh S.., et al., 2022. Very low frequency of the lactase persistence allele LCT-13910T in the Armenian population. Annals of Human Biology, 49(5–6), 260–262. doi:10.1080/03014460.2022.2126887.

 2. Enko D., et al., 2016. Lactase Non-Persistence Genotyping: Comparison of Two Real-Time PCR Assays and Assessment of Concomitant Fructose/Sorbitol Malabsorption Rates. Clinical laboratory vol. 62,4: 727-30. doi:10.7754/clin.lab.2015.150923.