VIENNALAB - Established innovations in diagnostics

Mutations in the methylenetetrahydrofolate reductase (MTHFR) gene are associated with decreased enzyme activity, which leads to hyperhomocysteinemia and toxic side effects of methotrexate therapy. ViennaLab assays identify patients predisposed to develop cardiovascular diseases or intolerance to methotrexate.

Hyperhomocysteinemia affects methotrexate sensitivity

  • Two common mutations in the MTHFR gene, 677C>T and 1298A>C, contribute to reduced enzyme activity which leads to elevated levels of homocysteine.
  • Homozygosity for 677C>T or compound heterozygosity for 677C>T / 1298A>C conveys a significantly higher risk for negative side-effects of methotrexate medication.
  • Identification of relevant mutations in the MTHFR gene is crucial for allowing an adequate and safe methotrexate therapy!

Product Details

MTHFR StripAssay® ref4-350
MTHFR 677C>T RealFast™ Assay ref7-160 7-163
MTHFR 1298A>C RealFast™ Assay ref7-170 7-173