VIENNALAB - Established innovations in diagnostics

Familial Mediterranean Fever (FMF) is characterized by recurrent episodes of fever accompanied by painful inflammatory events. The FMF StripAssays®  identify the most frequent mutations in the MEFV gene and risk factors for Amyloidosis.

Familial Mediterranean Fever

  • FMF is an inherited autoinflammatory disorder.
  • The most relevant complication associated with FMF is the build-up of protein deposits in serum (amyloidosis) severely affecting kidney and other organs.
  • Four different mutations in the MEFV gene (encoding the pyrin protein) have been identified as causes for the development of FMF.
  • The homozygous condition of the serum ­amyloid A (SAA) isotype SAA1.1 is significantly associated with AA amyloidosis and clinical severity in patients with FMF and rheumatoid arthritis (RA).
  • Prophylactic treatment with colchicine can prevent this and allow a normal life.
  • No ultimate cure available.

Product Details

FMF StripAssay® ref4-230
FMF-SAA1 StripAssay® ref4-390