Response to Thiopurine-based Therapy

• Thiopurines are widely used in the treatment of leukemias and autoimmune disorders, and as immunosuppressants after organ transplantation.
• Thiopurine compounds are converted to therapeutically inactive metabolites by the enzyme thiopurine S-methyltransferase (TPMT) which exists in different isoforms.
• Some TPMT isoforms have substantially reduced enzyme activity which leads to accumulation of higher thiopurine concentrations when receiving standard dosage. Myelosuppression, a toxic effect on the bone marrow, may thus occur.
• Identification of a patient’s individual TPMT isoform is crucial for avoiding toxic effects of thiopurines.

Product Details

PGX-TPMT StripAssay®

4-740

• Product Brochure
• Instructions of Use
• Literature