VIENNALAB - Established innovations in diagnostics

Oral anticoagulants like coumarin are commonly used to prevent and treat stroke. Genetic variants influence drug efficacy potentially leading to life-threatening wrong dosage. The PGX-Thrombo StripAssay® identifies the most relevant genetic variations influencing coumarin anticoagulation therapy.

Oral anticoagulants like coumarin are commonly used to prevent and treat stroke. Genetic variants influence drug efficacy potentially leading to life-threatening wrong dosage.

The PGX-Thrombo StripAssay® identifies the most relevant genetic variations influencing coumarin anticoagulation therapy.

Anti-Coagulation Therapy Response

  • Coumarins (vitamin K antagonists) are highly effective in prevention and treatment of stroke, myocardial infarction and venous thromboembolism.
  • Correct coumarin dosage is indispensable to avoid life-threatening bleeding (overdose) or lack of therapeutic effect (insufficient dose).
  • Variations in the genes responsible for coumarin antagonism of vitamin K and coumarin turnover influence drug affinity and thus its therapeutic effect.
  • Identification of genetic variants thus allows life-saving adjustment of coumarin anticoagulation therapy.

Product Details

PGX-Thrombo StripAssay® ref4-730